Impact of local ablation on interconnected channels within ventricular scar: mechanistic implications for substrate modification.

Background: The extent to which channels within scar are interconnected is not known. The objective of the study was to evaluate the impact of local ablation of late potentials (LPs) on adjacent and remote areas of slow conduction with simultaneous multipolar mapping.

Methods And Results: Analysis was performed on consecutive patients referred for ablation of scar-mediated ventricular tachycardia with double ventricular access.

A novel SCN5A mutation V1340I in Brugada syndrome augmenting arrhythmias during febrile illness.

Background: Mutations in the SCN5A gene, which encodes the cardiac sodium channel, have been implicated in the pathogenesis of Brugada syndrome (BrS). Febrile illnesses have been recognized to unmask and/or trigger the BrS phenotype. However, the pathophysiological mechanism has not been fully elucidated.

Ambulatory monitoring of congestive heart failure by multiple bioelectric impedance vectors.

Objectives: This study was designed to investigate the properties of multiple bioelectric impedance signals recorded during congestive heart failure (CHF) by utilizing various electrode configurations of an implanted cardiac resynchronization therapy system.

Background: The monitoring of CHF has relied mainly on right-side heart sensors.

Methods: Fifteen normal dogs underwent implantation of cardiac resynchronization therapy systems using standard leads.

Left ventricular twist mechanics in a canine model of reversible congestive heart failure: a pilot study.

Background: Left ventricular (LV) twist dynamics play an important role in LV systolic and diastolic function. The aim of this preliminary study was to investigate LV twist dynamics in a canine model of reversible congestive heart failure (CHF).

Methods: Pacing systems were implanted in adult dogs, and continuous chronic right ventricular pacing (230-250 beats/min) was applied until CHF induction.