Publications by authors named "Nilesh Ranjan"
Article Synopsis
- The PARCER trial provided evidence supporting the use of image-guided intensity-modulated radiation therapy (IG-IMRT) for cervical cancer, emphasizing the need for long-term financial analysis to integrate it into India's cancer treatment guidelines.
- A comparison of costs between IG-IMRT and three-dimensional conformal radiation therapy (3D-CRT) showed that IG-IMRT resulted in lower overall financial impacts, including treatment costs, adverse events, and toxicity management over time.
- Despite higher initial expenses for IG-IMRT, the study concluded 3D-CRT was financially less efficient, suggesting that guidelines should consider long-term costs for adopting advanced radiation treatments.
Background And Purpose: This post-hoc analysis was performed to report the impact of Image guided intensity modulated radiotherapy (IG-IMRT) and three-dimensional conformal radiotherapy (3D-CRT) across organ system and grades of toxicity within PARCER trial (NCT01279135). Primary endpoint of PARCER focused on grade ≥ 2 late gastrointestinal (GI) toxicity using Common Terminology Criteria for Adverse Events (CTCAE). We now analyze all adverse events using CTCAE and time and severity weighted toxicity reporting method (MOSES).
View Article and Find Full Text PDFBackground: Adverse event reporting in oncology trials lacks temporal description. We propose a toxicity summarizing method that incorporates time.
Methods: Patients recruited in a phase III trial (NCT01279135) that compared three-dimensional conformal radiotherapy (3DCRT) and intensity modulated radiotherapy (IMRT) for late toxicity in cervical cancer were included.
Early stage cervical cancer, stages IB1-2 and IIA1, can be treated with (chemo)radiation and brachytherapy or radical hysterectomy with or without further adjuvant (chemo)radiation. In a carefully selected cohort for surgery, traditionally a small proportion of patients would need adjuvant (chemo)radiation so that the therapeutic ratio is maximized. However, advances in radiation technology, specifically intensity modulated radiotherapy, have led to a reduction in treatment related adverse events.
View Article and Find Full Text PDFBackground & Objectives: : There is limited information available on the temporal course of late stage radiotherapy adverse effects. The present study reports on the temporal course of late toxicities after chemoradiation and brachytherapy.
Methods: : Women with cervical cancer who presented with late toxicity after (chemo) radiation were included in the study.