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View Article and Find Full Text PDFOral squamous cell carcinoma (OSCC) is a leading cause of mortality in India owing to the high percentage of tobacco chewers, smokers and alcohol consumption. OSCC is highly heterogeneous in nature; therefore poses a challenge in the treatment of the patient. To better understand the heterogeneity of the tumors, an in vitro cell line model is required.
View Article and Find Full Text PDFSecretory phospholipase A Group-IIA (sPLA-IIA) is involved in lipid catabolism and growth promoting activity. sPLA-IIA is deregulated in many pathological conditions including various cancers. Here, we have studied the role of sPLA-IIA in the development of cyclic alopecia and wound healing response in relation to complete loss of hair follicle stem cells (HFSCs).
View Article and Find Full Text PDFProblem: Role of autoantibodies to heat-shock protein 70 isoform, HSPA5, both alone or in combination with other antigenic peptides in epitope spreading and effect of high-dose dexamethasone to overcome this.
Method Of Study: Experimental autoimmune premature ovarian insufficiency mouse model generated by immunization with immunodominant epitopes of HSPA5 alone or in combination with other antigenic peptides. Two doses of dexamethasone treatment are given to the latter group.