Investigation of Therapeutic Effects of α-Mangostin on Thioacetamide-Induced Cirrhosis in Rats.

Objective: To determine the effects of alpha-mangostin on thioacetamide (TAA)-induced liver cirrhosis in rats.

Material And Method: Male Wistar rats were divided into 3 groups and treated with intraperitoneal injections of TAA (200 mg/kg) 3 times per week for per week for 8, 12 and 16 weeks, respectively. One subgroup was left untreated whereas the other two were treated either with 100 mg/kg α-mangostin or vehicle alone (80% DMSO, 20% water), which were administered intraperitoneally 3 times per weekfor a total of4 weeks.

Microscopic anatomy of the orbital Harderian gland in the common tree shrew (Tupaia glis).

The orbital Harderian gland of the common tree shrew (Tupaia glis) was investigated at the macroscopic and microscopic levels. In the glands of both sexes only one acinar cell type was found. The cell is characterized by the presence of numerous lipid vacuoles of variable size and by a small number of PAS-positive, electron-dense granules distributed throughout the cytoplasm, which are predominant at the basal portion of each acinar cell.