A Model for Reversible Electroporation to Deliver Drugs into Diseased Tissues.

Drug delivery through electroporation could be highly beneficial for the treatment of different types of diseased tissues within the human body. In this work, a mathematical model of reversible tissue electroporation is presented for injecting drug into the diseased cells. The model emphasizes the tissue boundary where the drug is injected as a point source.

Modelling of reversible tissue electroporation and its thermal effects in drug delivery.

Electroporation is a very useful tool for drug delivery into various diseased tissues of the human body. This technique helps to improve the clinical treatment by transferring drugs into the targeted cells rapidly. In electroporation, drug particles enter easily into the intracellular compartment through the temporarily permeabilized cell membrane due to the applied electric field.

Enhanced Drug Uptake on Application of Electroporation in a Single-Cell Model.

Electroporation method is a useful tool for delivering drugs into various diseased tissues in the human body. As a result of an applied electric field, drug particles enter the intracellular compartment through the temporarily permeabilized cell membrane. Consequently, electroporation method allows better penetration of the drug into the diseased tissue and improves treatment clinically.

A mathematical model of drug dynamics in an electroporated tissue.

In order to overcome the obstruction of cell membranes in the path of drug delivery to diseased cells, the applications of electric pulses of adequate potency are designated as electroporation. In the present study, a mathematical model of drug delivery into the electroporated tissue is advocated, which deals with both reversibly and irreversibly electroporated cells. This mathematical formulation is manifested through a set of differential equations, which are solved analytically, and numerically, according to the complexity, with a pertinent set of initial and boundary conditions.