Publications by authors named "Nilam Vetal"
Bromine inhalation mimics ischemia-reperfusion cardiomyocyte injury and calpain activation in rats.
Am J Physiol Heart Circ Physiol
January 2019
Halogens are widely used, highly toxic chemicals that pose a potential threat to humans because of their abundance. Halogens such as bromine (Br) cause severe pulmonary and systemic injuries; however, the mechanisms of their toxicity are largely unknown. Here, we demonstrated that Br and reactive brominated species produced in the lung and released in blood reach the heart and cause acute cardiac ultrastructural damage and dysfunction in rats.
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- Nicotine is absorbed into the bloodstream and is a key addictive element in both traditional tobacco and e-cigarettes, but its isolated effects on health are not well understood.
- Research using a rat model exposed to aerosolized nicotine revealed significant lung injury indicators, including increased lung inflammation and damage, as well as changes in blood cell counts.
- Nicotine exposure in airway epithelial cells showed detrimental effects, such as barrier loss and increased cell death, suggesting that nicotine from e-cigarettes could lead to serious pulmonary and systemic health issues.
Bromine (Br2 ) gas inhalation poses an environmental and occupational hazard resulting in high morbidity and mortality. In this review, we underline the acute lung pathology (within 24 h of exposure) and potential therapeutic interventions that may be utilized to mitigate Br2 -induced human toxicity. We discuss our latest published data, which suggest that an increase in heme-dependent tissue injury underlies the pathogenesis of Br2 toxicity.
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