A discrete Cu(Pd-bpy)L heterometallic compound with superoxide dismutase enzyme like activity.

A discrete heterometallic compound consisting of Cu(ii) and Pd(ii) units which mimicks Bovine Cu-ZnSOD has been synthesised in aqueous medium. Its superoxide radical ion scavenging activity is higher than the SOD activity of Scylla serrata tissues and comparable with the liver of Gallus domesticus.

Development of a targeted siRNA delivery system using FOL-PEG-PEI conjugate.

Receptor mediated delivery of siRNA enables silencing of target genes in specific tissues. Folate receptor (FR) is an attractive target for tumor-selective gene delivery. The focus of this study was to deliver the dihydrofolate reductase (DHFR) siRNA expressing plasmid and to silence the DHFR gene in FR positive KB cells, by complexing the plasmid with a folate-polyethylene glycol-polyethylenimine (FOL-PEG-PEI) conjugate, as a gene carrier.