Publications by authors named "Nikunjkumar K Patel"
Physiologically-based pharmacokinetic model of sparsentan to evaluate drug-drug interaction potential.
CPT Pharmacometrics Syst Pharmacol
February 2024
Article Synopsis
- - Sparsentan is a medication used to lower protein levels in urine for patients with primary IgA nephropathy who are at high risk of disease progression; it acts on both endothelin and angiotensin II receptors.
- - A comprehensive pharmacokinetic model was created to understand how sparsentan interacts with various drug-metabolizing enzymes and transporters, particularly focusing on its effects as both a victim and perpetrator of CYP3A4-related drug-drug interactions.
- - Simulation results indicated that the presence of a strong CYP3A4 inhibitor could more than double sparsentan’s exposure in the body, while complete inhibition of P-glycoprotein (P-gp) had minimal impact on its