Publications by authors named "Nikunj K Rout"
Background: The present study aims to evaluate the etiological spectrum with clinicopathological parameters and adverse outcomes of acute kidney injury (AKI).
Methods: A hospital-based prospective observational study was conducted for a spectrum of AKI in 103 AKI patients and their AKI-associated adverse outcomes. The AKI patients were included as per the KDIGO definition.
Background And Objectives: The matrix metalloproteinase 7 (MMP-7) level gets heightened in the urine samples of diabetic individuals with impaired renal function. Renal biopsy is seldom offered because of its invasive nature. These concerns spurred the investigation of relationships between urine MMP-7 levels and the renal function of diabetic individuals.
View Article and Find Full Text PDFAim And Objective: This questionnaire study aimed to evaluate the impact of a short educational session on the early diagnosis and management of acute kidney injury (AKI) among doctors specializing in fields other than nephrology, assessed through pre- and post-test scores. This educational study included resident doctors from various specialties for assessment.
Materials And Methods: The study enrolled different specialty resident doctors' departments and assessed them through questionnaires and assessment scores.
Article Synopsis
- Chronic kidney disease (CKD) patients are particularly susceptible to infections like Covid-19, and vaccination is emphasized as a crucial protective measure.
- A study analyzing 73 CKD patients who contracted Covid-19 found that the vaccinated group had better outcomes, including lower mortality rates (39.47%) compared to the unvaccinated group (65.71%).
- The results suggest that vaccination significantly helps reduce severe effects of Covid-19 and mortality in CKD patients, highlighting the importance of vaccination in this vulnerable population.
Background: Type 2 diabetes mellitus (DM) with nephropathy is a common complication in poorly controlled diabetes. Uncontrolled DM leads to intraglomerular vascular changes that cause physical injury to capillary walls, causing a profibrotic response in kidneys. The present study aimed to determine the association of hematological markers with microalbuminuria in early diabetic nephropathy.
View Article and Find Full Text PDFBackground Patients with chronic kidney disease and undergoing hemodialysis are at greater risk of developing COVID-19. In spite of vaccine efficacy, SARS-CoV-2 breakthrough infection has been reported in several studies. This study was carried out to assess if seroconversion could predict SARS-CoV-2 breakthrough infection in a cohort of vaccinated patients undergoing hemodialysis.
View Article and Find Full Text PDFIntroduction: Thrombotic thrombocytopenic purpura is a rare and fatal thrombotic microangiopathy characterised by a pentad of microangiopathic haemolytic anaemia, thrombocytopenia, renal abnormalities, neurological abnormalities, and fever. Due to ineffective erythropoiesis, vitamin-B12 deficiency may rarely present as haemolytic anaemia.
Case Report: We report a case of a 42-year-old vegetarian female presenting as vitamin B12 deficiency anaemia found to have concomitant TTP, responding to plasmapheresis, corticosteroids, and rituximab therapy.
Article Synopsis
- Diabetes mellitus (DM) is linked to serious kidney complications, with chronic inflammation playing a key role in type 2 diabetes progression, potentially detectable through simple inflammatory markers.* -
- A study involving 90 type 2 diabetic patients tested the relationship between neutrophil-to-lymphocyte ratio (NLR) and red blood cell distribution width (RDW) and the presence of microalbuminuria.* -
- Results indicated a significant correlation, especially with NLR showing promise in predicting microalbuminuria, suggesting these markers are cost-effective tools for early kidney disease detection in diabetic patients.*
Introduction: The aim of this study was to evaluate the immunohistochemical expression of C4d in native renal biopsies of proliferative glomerular diseases, complement pathways in these diseases, and assess the relationship of C4d with histological and clinicopathological parameters, other complement proteins, and immunoglobulin markers.
Methods: This cross-sectional study was conducted during the year 2018-19 involving 107 native renal biopsies with histologically diagnosed cases of proliferative glomerular diseases. C4d immunohistochemical evaluation of renal tissue sections was performed using polyclonal antihuman C4d as the primary antibody.