Renal failure due to rectal neoplastic polyp: McKittrick-Wheelock syndrome-a case report.

Background: McKittrick-Wheelock syndrome is an uncommon and severe disorder caused by large hypersecretory tumors located in the distal colorectal area. Excessive secretion from adenomas is an unusual clinical manifestation that leads to severe electrolyte and fluid depletion, subsequently resulting in kidney injury. Successful treatment relies on quick and cooperative decision-making for timely intervention.

Experimental cadmium poisoning in sheep.

Pathomorphological investigations of internal organs were made in sheep given sublethal doses of cadmium. Early histological damages in kidneys were established by renal biopsy in some experimental animals. The main histological changes were characterized by granular degeneration in proximal tubules and glomerular endothelial proliferation in kidneys, granular degeneration in hepatocytes, pericapillary oedema and activation of capillary endothelium and Kupffer cells in liver, oedematous and degenerative changes in cerebrum and in the region of Purkinje cells of cerebellum, hyperplasia and proliferation of alveolar epithelium and perivascular or peribronchial mononuclear cell infiltration in lung, and degenerative changes in the medulla and zona glomerulosa of adrenal glands.

Effect of estradiol on the protein synthesis in the female rat liver in vitro.

The incorporation of 14C-leucine in protein, as well as in aminoacyl adenylate and aminoacyl-tRNA (AA-tRNA) from the liver of mature female rats (controls, ovariectomized and treated after the ovariectomy with daily doses of 20 micrograms 17, beta-estradiol-dipropionate/100 g body weight for 11 days), was investigated under conditions of a cell-free protein-synthesizing system containing isolated microsomes and cytosol. The ovariectomy causes reduced incorporation of the label in protein and in AA-tRNA, while hormonal treatment compensates this decrease either partially or completely. Data are presented which suggest that the hormone probably increases the supply of macroergic components and free amino acids to the hepatocytes, and that it also increases the sensitivity to cycloheximide and tetracycline.

Binding of cytosol 3H-17, beta-estradiol to cytosol receptors in the liver of female rats.

The article is a study of the specific binding of 3H-17, beta-estradiol to cytosol receptors in the liver of female, sexually mature albino rats: sham-operated, ovariectomized and treated after the ovariectomy with 17-beta-estradiol (in doses of 20 micrograms/100 g body weight for 11 days). The binding of the labelled hormone in the liver cytosol isolated from ovariectomized rats is considerably reduced compared with the sham-operated animals. In the cytosol from the liver of the estradiol-treated rats the formation of a hormone-receptor complex is substantially increased compared with the ovariectomized animals.

Effect of estradiol on DNA and protein synthesis in rat liver in vivo.

The article studies the effect of 17, beta-estradiol on the binding of cytosol estradiol-receptor complex with chromatin isolated from the liver of female albino rats (sham-operated, ovariectomized and treated after the ovariectomy with 20 micron hormone/100 g body weight for 11 days) and sexually mature male albino rats. Higher binding of the complex is found for the female animals compared with the males. Parallel experiments are made to study the incorporation of 3H-thymidine and 14C-glycine in vivo, in acid-soluble and acid-insoluble liver fractions of female rats, respectively, which is used as a basis for assessing the rate of DNA and protein synthesis.