Publications by authors named "Nikoline Nygaard"
Background: Gingivitis in response to biofilm formation may exhibit different trajectories. The purposes of the present study were to characterize the composition of the supragingival microbiota and salivary cytokine and protein levels in healthy individuals with different gingivitis patterns, to test the hypothesis that manifestations of gingivitis associate with specific profiles in terms of supragingival microbiota, salivary cytokines, and proteins.
Methods: Forty orally and systemically healthy individuals refrained from all oral hygiene procedures for a period of 14 days, followed by a resolution period of 14 days with regular oral care.
Article Synopsis
- The study explores how host genome variants influence oral microbial communities, linking the mouth's bacteria to both oral and overall health in 610 Danish adults.
- Researchers identified six specific single nucleotide polymorphisms (SNPs) associated with varying abundances of oral bacteria and found that one SNP significantly exceeded the study's significance threshold.
- The findings suggest a complex relationship between genetics, oral microbiota, and metabolic health, indicating a need for combined studies in these areas to better understand health outcomes.
Background: Since 1972 The National Child Odontology Registry has collected data on the oral health of most of all Danish children and adolescents. However, comprehensive information on the registry has not previously been available, making it difficult to approach and use the registry for research purposes.
Methods: By combining historical documentation and simple descriptive statistics we provide an overview of major events in the timeline of The National Child Odontology Registry and discuss how they impact the available data.
Article Synopsis
- Previous research suggests that salivary microbiota could be a useful indicator for both oral and systemic diseases, but it's important to consider health status and lifestyle factors before using it for screening purposes.
- The ADDITION-PRO study analyzed saliva samples from 746 participants using advanced genetic techniques to identify how different health and lifestyle variables affect salivary microbial diversity.
- Key findings indicated that factors like glycemic status, HbA levels, sex, smoking, and alcohol intake significantly impact salivary microbial composition, with smoking alone showing a strong link and high accuracy for detection based on saliva analysis.