Publications by authors named "Nikolina Velizarova Rusenova"
The purpose of this study was to analyze ciprofloxacin and lomefloxacin penetration into the anterior eye tissues after topical instillation in healthy rabbits and with experimental Staphylococcus aureus endophthalmitis. Additionally, effect of diclofenac sodium eye drops on the distribution of both fluoroquinolones in the inflamed eye tissues was investigated. An intense protocol with frequent antibiotic administration was chosen.
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- ABC transport proteins are influenced by various factors, especially during inflammatory reactions caused by infections, affecting how drugs are absorbed and processed in the body.
- Fluoroquinolones, like danofloxacin mesylate and enrofloxacin, were studied for their impact on the expression of drug transporters MDR1 and MRP2 in broilers with colibacillosis, revealing that treatment helped restore levels of MDR1 mRNA.
- The findings highlight the clinical significance of fluoroquinolone treatment, as it not only improves health in infected birds but also supports the protective function of ABC transporters against pathogens and toxins.
Fluoroquinolones are extensively used in the treatment of systemic bacterial infections in poultry, including systemic Escherichia coli bacillosis, which is a common disease in turkey flocks. Marbofloxacin has been licensed for use in various mammalian species, but not as yet for turkeys, although its kinetic properties distinguish it from other fluoroquinolones. For example, the longer half-life of marbofloxacin in many animal species has been appreciated in veterinary practice.
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