Publications by authors named "Nikolett Virag"
Article Synopsis
- The lymph gland in Drosophila larvae serves as a model for understanding blood cell development, featuring different zones responsible for progenitor and differentiated hemocyte functions.
- Previous studies indicated that the Headcase (Hdc) factor is crucial for controlling hemocyte differentiation in this organ, but how it operates at the molecular level was unclear until now.
- The current study reveals that Hdc regulates differentiation by inhibiting the insulin/mTOR signaling pathway, impacting both the niche environment and the progenitor cells autonomously, thereby providing insights into blood stem cell maintenance that could apply to vertebrates.
