Publications by authors named "Nikoleta Delivanoglou"
Article Synopsis
- - RNA editing is an epitranscriptomic process involving ADAR and APOBEC enzymes that can alter RNA and plays a significant role in various diseases, including autoimmune diseases like multiple sclerosis (MS).
- - The study focused on its impact in a model called experimental autoimmune encephalomyelitis (EAE), which mimics aspects of MS, by analyzing microglia data and testing transgenic mice lacking APOBEC-1.
- - Findings revealed reduced RNA editing events during disease progression in knock-out mice, leading to worse EAE symptoms, suggesting RNA editing regulates mechanisms that may apply to MS and other neurodegenerative disorders.
Hypoxia is the lack of sufficient oxygenation of tissue, imposing severe stress upon cells. It is a major feature of many pathological conditions such as stroke, traumatic brain injury, cerebral hemorrhage, perinatal asphyxia and can lead to cell death due to energy depletion and increased free radical generation. The present study investigates the effect of hypoxia on the unfolded protein response of the cell (UPR), utilizing a 16-h oxygen-glucose deprivation protocol (OGD) in a PC12 cell line model.
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