New Principles of Development of Preparations for Immunoprophylaxis.

In the development of new vaccine the fate of preparation depends on three main factors: potential to decrease morbidity and benefits from vaccine use; the risk of post vaccinal complications and possible damage from vaccination; the cost of vaccine and economic advantages. By basic parameters, dealing with safety and effectiveness, home immunological preparations, first of all vaccines used in framework of vaccination calendar, meet all the requirements of WHO. However, absolutely safe vaccines don't exist in the world.

Mediators of Immune Response.

The classification of mediators of immune response is referred to the organs, in which they are formed, to the cells-producers and target cells, to the character of their action, to the physico-chemical characteristics, to the phases and types of immune response, on which they exert their effects. The secretion of cytokines may be increased in many pathological conditions, and cytokines may appear in blood circulation. The high level of some cytokines, first of all with pro-inflammatory properties, is unfavorable sign.