Publications by authors named "Nikolay S Li-Zhulanov"
Article Synopsis
- Researchers discovered two new types of TDP1 inhibitors that can effectively inhibit the TDP1 enzyme, crucial for DNA repair, at low concentrations, with the strongest compound showing an IC value of 0.65 μM.
- The inhibitors were synthesized from monoterpene compounds and they demonstrated a synergistic effect when tested with the cancer drug topotecan in HEK293FT cells with functional TDP1.
- This synergy suggests that using non-toxic inhibitors alongside existing cancer therapies can improve treatment effectiveness while minimizing harmful side effects.
A Novel Small Molecule Supports the Survival of Cultured Dopamine Neurons and May Restore the Dopaminergic Innervation of the Brain in the MPTP Mouse Model of Parkinson's Disease.
Oleg V Ardashov Alla V Pavlova Arun Kumar Mahato Yulia Sidorova Ekaterina A Morozova Nikolay S Li-Zhulanov
ACS Chem Neurosci
October 2019
Article Synopsis
- Researchers synthesized new compounds called monoepoxides from a previously studied monoterpenoid that reduced Parkinson's disease symptoms in animal models.
- One specific epoxide was identified that effectively restored movement in mice with Parkinson's and successfully crossed the blood-brain barrier.
- This epoxide showed strong protective effects on dopamine neurons and could promote the regrowth of these neurons, suggesting its potential as both a treatment and a neuroprotective drug for Parkinson's disease.