Publications by authors named "Nikolay Nemirovich-Danchenko"
The Open Genes database was created to enhance and simplify the search for potential aging therapy targets. We collected data on 2402 genes associated with aging and developed convenient tools for searching and comparing gene features. A comprehensive description of genes has been provided, including lifespan-extending interventions, age-related changes, longevity associations, gene evolution, associations with diseases and hallmarks of aging, and functions of gene products.
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- The study investigates the potential of overexpressing ferritin, an iron-binding protein, to visualize neurogenesis non-invasively using MRI, especially after a stroke when neurogenesis is enhanced.
- It involved injecting a viral vector carrying ferritin and a control protein (eGFP) into rats that underwent a stroke or sham surgery, followed by multiple MRI scans to track changes over 28 days.
- The results revealed unique MRI signal patterns in the brains of stroke-injected rats, indicating successful visualization of neurogenesis, particularly in areas surrounding the damaged tissue and near the lateral ventricle.
Cuprizone-induced demyelination in mice is a frequently used model in preclinical multiple sclerosis research. A recent quantitative clinically-targeted MRI method, fast macromolecular proton fraction (MPF) mapping demonstrated a promise as a myelin biomarker in human and animal studies with a particular advantage of sensitivity to both white matter (WM) and gray matter (GM) demyelination. This study aimed to histologically validate the capability of MPF mapping to quantify myelin loss in brain tissues using the cuprizone demyelination model.
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