Three paralogues in lampreys and gnathostomes-brothers or cousins?

is a key regulator of the early development of the vertebrate forebrain and sensory organs. In this study, we describe for the first time three paralogues in lamprey, representative of one of two basally diverged lineages of vertebrates-the agnathans. We also first describe three genes in sterlet-representative of one of the evolutionarily ancient clades of gnathostomes.

Differential expression of duplicated LDH-A genes during temperature acclimation of weatherfish Misgurnus fossilis. Functional consequences for the enzyme.

Temperature acclimation in poikilotherms entails metabolic rearrangements provided by variations in enzyme properties. However, in most cases the underlying molecular mechanisms that result in structural changes in the enzymes are obscure. This study reports that acclimation to low (5 degrees C) and high (18 degrees C) temperatures leads to differential expression of alternative forms of the LDH-A gene in white skeletal muscle of weatherfish, Misgurnus fossilis.