Human papilloma virus (HPV) molecular diagnostics.

Human Papilloma Virus (HPV) is becoming a menace worldwide, especially to the developing world, due to its involvement in a variety of malignancies, with cervical cancer being the most important and prevalent. There are many HPV types; HPV 16/18 are the most carcinogenic but few others are also characterized as high-risk (HR). They can cause a variety of low- or high-grade cellular abnormalities, most frequently detected in a routine Pap test.

Presence of high-risk human papillomavirus sequences in breast cancer tissues and association with histopathological characteristics.

Objective: To examine the presence of human papillomavirus (HPV) in breast cancer tissues.

Design And Methods: Four different PCR methods for detection and verification of genital HPVs were applied in frozen breast cancer specimens. Tumors were also evaluated for various histopathological parameters.