Pharmacokinetic study for the establishment of bioequivalence of two inhalation treatments containing budesonide plus formoterol.

Objectives: The aim of this study was to compare lung deposition and assess the bioequivalence of two formulations containing budesonide and formoterol and being delivered via Elpenhaler and Turbuhaler, respectively. A pharmacokinetic (PK) study was conducted.

Methods: An open, randomized, two-sequence, two-period, crossover, single-dose study in 100 asthmatic patients under fasting conditions was performed.