Publications by authors named "Nikolaos Gkalapis"
Article Synopsis
- This study aimed to examine the degeneration of peripapillary retinal nerve fiber layer (pRNFL) in patients with late-infantile neuronal ceroid lipofuscinosis type 2 (CLN2) disease and to assess pRNFL thickness using optical coherence tomography (OCT) as a potential indicator of disease progression.
- The research involved 20 diagnosed patients who received regular enzyme replacement therapy, with OCT imaging conducted under anesthesia; results showed a significantly lower mean pRNFL thickness compared to healthy children, indicating degeneration.
- Results highlighted that pRNFL thickness correlated strongly with age and clinical scales used to evaluate motor and language abilities, suggesting that pRNFL can serve as a useful biomarker for monitoring the progression of CL
