Publications by authors named "Nikolaos G Gavalas"
Article Synopsis
- Members of the α-thymosin family, particularly prothymosin α (proTα) and its peptide proTα(100-109), have been shown to boost T helper type 1 (Th1) immune responses and enhance antitumor T cell activity both in the lab and in living organisms.
- Safety assessments in silico, in human cells, and in healthy mice indicated that proTα and proTα(100-109) are likely non-toxic and do not promote harmful effects, similar to the established safety of thymosin alpha 1 (Tα1).
- Overall, the research suggests that proTα and proTα(100-109) are safe at high concentrations and maintain
Background: Overexpression of c-Myc is commonly seen in human ovarian cancers, and this could be a potentially novel therapeutic target for this disease. JQ1, a selective small-molecule BET (Bromodomain and extraterminal domain family) bromodomain (BRDs) inhibitor, has been found to suppress tumour progression in several cancer cell types.
Results: Using a panel of ovarian cancer cell lines and primary cell cultures from human ovarian cancer ascites, we demonstrated that JQ1 significantly suppressed cell proliferation and induced apoptosis in an ovarian cancer cell by targeting BRD4 and c-Μyc.