The Gyaros island marine reserve: A biodiversity hotspot in the eastern Mediterranean Sea.

Since July 2019, Gyaros island in the central Aegean Sea, enjoys the status of a partial Marine Protected Area (MPA), allowing for exploitation by small-scale fishers following specific spatio-temporal restrictions. The need for assessing the effectiveness of the MPA in the future, led MAVA Foundation to fund a knowledge survey project aiming to serve as a baseline for future reference. A series of experimental fishing surveys took place with static nets, the outcomes of which are presented herein.

Light intensity distribution in images from rigid endoscopes used in minimal access sinus surgery.

Objectives/hypothesis: To investigate the pattern of intensity levels in images generated by the two most commonly used rigid endoscopes angulations in sinus surgery: 0° and 30°.

Methods: An enclosed light box containing an optical square grid, under endoscope illumination set just below saturation level, was used for measuring light distribution levels across test images. Endoscopes with 0° and 30° angulations were tested at 10 mm from the grid, typical for sinus surgery.

Genomic and Transcriptomic Determinants of Therapy Resistance and Immune Landscape Evolution during Anti-EGFR Treatment in Colorectal Cancer.

Despite biomarker stratification, the anti-EGFR antibody cetuximab is only effective against a subgroup of colorectal cancers (CRCs). This genomic and transcriptomic analysis of the cetuximab resistance landscape in 35 RAS wild-type CRCs identified associations of NF1 and non-canonical RAS/RAF aberrations with primary resistance and validated transcriptomic CRC subtypes as non-genetic predictors of benefit. Sixty-four percent of biopsies with acquired resistance harbored no genetic resistance drivers.

Effect on Overall Survival of Locoregional Treatment in a Cohort of De Novo Metastatic Prostate Cancer Patients: A Single Institution Retrospective Analysis From the Royal Marsden Hospital.

Background: The optimal management of the primary tumor in metastatic at diagnosis (M1) prostate cancer (PCa) patients is not yet established. We retrospectively evaluated the effect of locoregional treatment (LRT) on overall survival (OS) hypothesizing that this could improve outcome through better local disease control and the induction of an antitumor immune response (abscopal effect).

Patients And Methods: M1 at diagnosis PCa patients referred to the Prostate Targeted Therapy Group at the Royal Marsden between June 2003 and December 2013 were identified.

Defining optical distortion in rigid endoscopes.

Objectives/hypothesis: To describe lens and perspective distortion using new measures that have practical meaning to the surgeon, and to apply these measures to show the extent of optical distortion in rigid endoscopes used in endoscopic sinus surgery.

Study Design: Laboratory measurements on rigid endoscopes.

Methods: Barrel and perspective distortion were measured in 4-mm diameter 0°, 30°, 45°, and 70° rigid sinus endoscopes.