Experimental osteomyelitis caused by methicillin-resistant Staphylococcus aureus treated with a polylactide carrier releasing linezolid.

Background: The effectiveness of a new delivery system consisting of polymerized dilactide (PLA) with incorporated linezolid was investigated in a rabbit model as a means of treating methicillin-resistant Staphylococcus aureus (MRSA) osteomyelitis.

Methods: The PLA-linezolid system was prepared after thorough stirring of PLA with linezolid at a 10:1 ratio. Experimental osteomyelitis was established in 40 rabbits by a modification of the Norden model with MRSA as the test isolate.

Finite element method in internal and hybrid external fixation of tibial condylar fractures: a comparative application study.

The treatment of tibial condylar fractures requires the preparation of personalized treatment, customized to the needs of the patient, that will take into consideration his or her personal activities. The purpose of the present study was (1) the development, by using the finite elements method, of a 3-dimensional, highly discrete, simulation model of the knee-tibia, (2) the creation of 6 types of fractures in this model according to Schatzker's classification, (3) the insertion of materials for internal and hybrid external fixation, (4) the recording of the model's biomechanical behavior during the load, and (5) the discovery of findings regarding the stability of the internal and hybrid external treatment methods. The results from the resolution procedure showed that the values of maximum displacements in every fracture type except type III were reduced in the models with internal fixation.