COMPARATIVE ANALYSIS OF MEMORY AND BEHAVIORAL CHANGES AFTER RADON-CONTAINED MINERAL WATER INHALATION THERAPY IN AGED RATS.

Unlabelled: This research article elucidates the pivotal role of radiopharmacy in the contemporary landscape, underscoring its potential therapeutic efficacy in addressing symptoms associated with aged-related neurocognitive processes. Clinical trials, characterized by the judicious application of modest radiation doses, exemplified by low-dose radon, have yielded affirmative outcomes in the amelioration of aged, related symptoms.

Material And Methods: The study was conducted on an animal model.

Biological therapies for the treatment of psoriasis in pediatrics.

Introduction: Psoriasis is a multifactorial, immune-mediated condition with predominant skin involvement. It may develop at any age. In one-third of patients, the first symptoms of psoriasis start during childhood or adolescence.

Viral Infections May Be Associated with Henoch-Schönlein Purpura.

Henoch-Schönlein purpura or IgA vasculitis is the most common type of pediatric vasculitis that may affect adults as well. It is classified as a type of small-vessel vasculitis. It can cause cutaneous and systemic symptoms with a minority of patients developing kidney failure.

EFFECT OF RADIATION ON AGING PROCESSES AND TELOMERE LENGTH.

Telomeres are the ending areas of chromosomes - protective «caps» that ensure the stability of chromosomes. Telomere shortening is one of the most important biological signs of aging and is involved in cellular aging and the «mitotic clock» mechanism. One of the known mechanisms of the impact of radiation on the aging process is damage to telomeres by free radicals.

The effect of balneotherapy on the oxidative system and changes in anxiety behavior, enhanced by low doses of radon.

Purpose: The aim of our research was to study the effect of radon hormesis balneotherapy using natural thermal waters of Tskaltubo spring, practically, its effect on oxidant and antioxidant systems and anxiety reactions in rats. Radon is a natural gas with radioactive properties, which can have a hermetic effect when used in small doses. Radon was used to activate antioxidant mechanisms in rats, which resulted an anxiolytic effect and positively enhanced the effect of balneotherapy.

RADON HORMESIS IN EPILEPTIC PATHOGENESIS AND PREDICTORS OF OXIDATIVE STRESS.

Numerous experimental and clinical studies have shown that oxidative stress (OS) plays an important role in the development of epilepsy. The epileptic seizures themselves are caused by OS and, under conditions of a hypermetabolic state, cause an intensive production of reactive oxygen species (ROS) in the brain. The reason for this is called a change in the energy balance in the brain.

STUDY OF THE HYGIENIC CHARACTERISTICS OF THE ORAL CAVITY UNDER THE COMPLEX EFFECT OF PHOTODYNAMIC THERAPY AND TSKALTUBO SPRING WATER RADON HORMESIS.

The goal is to study the method of photodynamic therapy, which has become widespread in recent decades. This method of treatment has gained popularity in the treatment of both oncological and non-oncological inflammatory diseases in dentistry and other medical fields. We can conclude that the complex action of Rada Dent and Tskaltubo water (inhalation of Tskaltubo water and its use as rinses) leads to a gradual reduction and eventual eradication of the inflammatory process in the case of periodontitis.

IMPACT OF HOUSEHOLD MICROWAVE OVEN NON-IONIZING RADIATION ON BLOOD PLASMA CORTISOL LEVELS IN RATS AND THEIR BEHAVIOR.

In medical literature is known that the electromagnetic waves own a harmful effect on human organism. Is convinced shows that surround household microwave oven exist certain quantity of non-ionizing radiation leak. The aim of the present work is study the effect of non-ionizing radiation, emitted by household microwave oven, on the body weight, emotional and locomotor activity and cortisol blood plasma level in rats.

INHALATION THERAPY BY RADON FROM TSKHALTUBO REGION IN CLINICAL AND BIOCHEMICAL STUDIES IN PATIENTS WITH PERIODONTITIS.

The study of clinical and biochemical processes in the oral cavity determined changes in the entire biochemical spectrum of the oral cavity in 132 patients aged 20-40 years with various forms of periodontitis. Similar follow-ups were divided into three groups in the main group with mild to moderate severity of periodontitis with a 10-day intake of radon, 43 patients were united into the control group with no pathological changes in periodontal tissue however. Inhalation and rinsing with radon-containing water causes a decrease in LDH levels in the oral cavity.

[COMPLEX STUDY OF BIOLOGICAL EFFECT OF TSKHALTUBO RADON WATER INHALATION].

The effect of EMF of high frequencies (mobile phones and computers) and the action of radon therapeutic procedures (phenomenological and influencing therapeutic factors) is not still generally known. In addition, we are constantly under the influence of different EMF frequencies, the study of which also deserves attention. The aim of the work is detailed analysis of alpha radiation Tskhaltubo water effect.

COMPLEX STUDY OF MEDICINAL PROPERTIES OF RADON IN MINERAL WATER OF TSKALTUBO AND ORAL CAVITY MINERALIZATION RECOVERY IN PATIENTS WITH PERIODONTITIS.

Supersaturation of hydroxyapatite is very important in order to preserve the homeostasis of mineral metabolism in the oral cavity. This indicates to the ability of saliva to preserve the homeostasis of the tooth tissues. So it is very important to use inhalations and rinses with Tskhaltubo mineral water.

CHANGES IN TOOTH HARD TISSUE MINERALI-ZATION AND BLOOD RHEOLOGY IN HEALTHY ADOLESCENTS AND THOSE WITH THYROID DYSFUNCTION.

Thyroid dysfunction causes spreading and development of caries in the teeth and changes in periodontal tissues. In addition, it causes changes in peripheral blood flow and mineralization, local transcapillary metabolism causes changes in blood rheology. There are only few works in this direction and, therefore, the purpose of our research was to find out how the mineralization and the rheological properties of blood are changed in lesion of periodontal tissue on a background of thyroid dysfunction.

[THE LEVEL OF BENZ(A)PIREN IN TOBACCO SMOKE].

The medical problems of the environmental pollution with products of tobacco smoke are relatively known. The question of separate components of tobacco smoke, factors such a puff-volume, rate, distance, frequency, length of butt in the environment air is not well understand and should further be investigated. It is shown the dependence of the process on the following factors: physic-chemical parameters of atmospheric environment, brand of tobacco product, activity of smoking process.

[The effects of grape seed and coriander oil on biochemical parameters of oral fluid in patients with periodontitis].

Biochemical changes that are taking place in patients with periodontitis 1 and 2 the quality of the individuals place in a laqtatdegidrogenazis, alkaline phosphatase activity increase and reduced activity amilazais. Therefore we can conclude that, there is an increase in superoxide substances, which causes an increase in the oral cavity patobakteriebis and quality of periodontitis. The grape seed and coriander oil is of vegetable origin and antioxidant drugs.

[Influence of radiation on survivability, behavior and neurochemical correlates of rats].

The aim of the work was to study the dependence of individual radiosensitivity of white and black rats on radiation. The rats under study were derived from a cross between black and white rats and called Ratus Ratus-Georgia. Comparative radiosensitivity of white (Wistar) and black rats was studied at a total exposure with sublethal and lethal doses (5, 7 and 9 Gy).

Physical predictors, behavioural/emotional attributes and neurochemical determinants of dominant behaviour.

Significant differences in physical and behavioural/emotional/cognitive predictors and attributes, as well as of neurochemical inducers of behaviour, between dominant and subordinate animals are discussed. It is still unknown whether these factors are the causes of differences between dominants and subordinates, or vice versa whether the differences between dominants and subordinates are the origin of differences in these factors. The possibility is discussed that no differences exist among juveniles in the concentrations of neurochemical agents (known in the literature as determinants of dominance) between the brains of future dominants and future subordinates.

[The fatty acid composition of Ruta graveolens seed oil and its byological activity].

Using high-performance liquid chromatography methods are qualitatively and quantitatively identified most biological important high fatty acids, contained in Ruta graveolens seed oil grown on the experimental plot of Kutateladze Institute of Pharmakochemistry (Georgia) and compare its biological activity. Their relative concentration is expressed as percentages of the total fatty acid component. The sample contained the range of fatty acids from С12:0 to С22:0.

[The fatty acid composition of peach oil and its biological activity].

Using high-performance liquid chromatography methods (Cromatograph PTC-1, repractometer R-401, column Bondopaс C18) were quantitatively and qualitatively identified most biological important high fatty acids, contained in peach oil (Persica Vulgaris) from ost region of Georgia (Kacheti). Their relative concentrations are expressed as percentages of the total fatty acids components. The chromatography investigation shaved, that the oil contained 12,98±1,0mg% linoleic, 9,97±0,3 mg% palmitic, 4,82±0,2 mg% linolenic, 3,58±0,1 mg% begenic and 2,16±0,1 mg% arachinic acids.

Seroprevalence of brucellosis in livestock within three endemic regions of the country of Georgia.

Brucellosis is the one of most common livestock zoonoses in Georgia, resulting in significant economic losses. Livestock were sampled in three regions of Georgia (Kakheti, Kvemo Kartli, Imereti). Districts that historically reported high numbers of brucellosis related morbidity were selected for serological, bacteriological and molecular surveys.

[The pyretroind pesticides lambda-cigalothrines influence on composition of free aminoacids in tissue of fish in Alazani River].

The aim of the research was to study toxic effect of lambda-cigalothrin, on quantitative contents of free amino acid in muscle, liver and in brain of fishes in r. Alazani. It was found that under the action of lambda-cigalothrin total amount of free amino acid in fish's tissue was increasing, contents of glycine, asparagine and glutamine acids, alanine and cysteine also increased.

[The most biological important constances of Rkatsiteli grape oil and its effect as a 5% and 10% food-additive].

In this paper, using high-performance liquid chromatography methods were quantitatively and qualitatively identified most biological important high fatty acids, contained in Rkatsiteli grape seed oil of 2010 years crop in Signakhi region of Georgia. The chromatography investigation showed, that the grape seed oil contained 61% linolic acid, 19% oleic, 8% palmitic, 4.5% stearic, 1.

[The fatty acid composition of Rkatsiteli grape seed oil and its effect as a food-additive].

In this paper high fatty acids in the Rkatsiteli grape seed oil were qualitatively and quantitatively identified. In the Rkatsiteli grape seed oil linolenic, oleic, palmitic, stearic, palmitooleinovaya, linoleic and arachidonic acids were identified. The impact of Rkatsiteli grape seed oil as a dietary supplement on the contents of fatty acid synthase and lipids in the livers of mice were determined.

[The influence of electromagnetic field on active avoidance reaction, biogenic amines and amino acids in brain of rats in spite of backround of food-stuff addition seratonus].

Amino acid preparation "Seratonus" not only regulates the action of stressors, but its intake in usual conditions strengthens an animals attitude toward danger, takes off development of excitement process, that is clearly shown by quantity and ratio of biogenic amines and amino acids. "Serotonus" develops optimal range of metabolism of above-mentioned substances that lead to right solve by animals of given tasks, in particular to improvement of active avoidance conditional reactions, that is clearly indicated by metabolism of amino acids as are phenylalanine and tryptophan, that is synthesizer of thirosine. While the latter takes part in synthesis of dopamine and noradrenalin and tryptophan regulates metabolism of serotonin.

[Action of ACTH fragment on the rates aggressive behavior and the distribution of transmitter amino acids in the brain structures].

Neurochemical experiments revealed that the metabolism of the amino acids in the cerebral hemispheres has a tendency to an increase of the ratio of aspartic acid to taurin and GABA with a simultaneous enhancement of oxidation. It is generally accepted that ACTH fragments activate limbic syctem and regulate instinctive - motivated behavior. The neuroactive properties of short fragments of ACTH (4-7) are considered to be the peptides of memory and behavior.

[Aggressive behavior and radiosensitivity in rats'].

This paper aims to present the study of rats' individual radiosensitivity dependence on their individual aggressiveness. On total irradiation in sublethal doses (1.0, 1.