Publications by authors named "Nikolai V Zharkov"
Background: One of the tasks of anticancer photodynamic therapy is increasing the efficacy of treatment of cancer nodes with large (clinically relevant) sizes using near-infrared photosensitizers (PS).
Methods: The anticancer efficacy and mechanisms of the photodynamic action of PS based on polycationic derivatives of synthetic bacteriochlorin against Lewis lung carcinoma were studied in vitro and in vivo.
Results: It was found that studied PS have high phototoxicity against Lewis lung carcinoma cells: the IC values were about 0.
On the mechanisms of photodynamic action of photosensitizers based on polycationic derivatives of synthetic bacteriochlorin against human lung cancer cells A549 (in vitro study).
Evgeniya A Kogan Gennady A Meerovich Saida Sh Karshieva Elena A Makarova Igor D Romanishkin Nikolai V Zharkov
Photodiagnosis Photodyn Ther
September 2022
Article Synopsis
- Researchers are investigating the effectiveness of near-infrared photosensitizers (PS) derived from synthetic bacteriochlorin to treat large cancer tumors, specifically focusing on A549 human lung cancer cells.
- The study employs various immunocytochemical and morphological methods to analyze how these PS affect cancer cell behavior, including inducing cell death (necrosis and apoptosis) and reducing cancer cell proliferation.
- Findings reveal that tetracationic and octacationic PS exhibit significant phototoxicity against A549 cells, with effective concentrations notably lower under light than in the dark, suggesting these compounds could be promising for enhancing photodynamic therapy outcomes.