Publications by authors named "Nikolai Mikhailovich Bazhin"
Complex V or FF-ATPase is a multimeric protein found in bioenergetic membranes of cells and organelles like mitochondria/chloroplasts. The popular perception on Complex V deems it as a reversible molecular motor, working bi-directionally (breaking or making ATP) via a conformation-change based chemiosmotic rotary ATP synthesis (CRAS) mechanism, driven by proton-gradients or trans-membrane potential (TMP). In continuance of our pursuits against the CRAS model of cellular bioenergetics, herein we demonstrate the validity of the murburn model based in diffusible reactive (oxygen) species (DRS/DROS).
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- Contemporary beliefs about oxygenic photosynthesis are challenged, with the Murburn model presented as a new alternative explanation.
- In this model, reactive species play a key role, and all pigments are considered to be photo-redox active within a stochastic mechanism.
- NADPH is synthesized through straightforward electron transfers instead of a complex electron transport chain, and the model suggests a more dispersed oxygen production process.
Since mid-1970s, the proton-centric proposal of 'chemiosmosis' became the acclaimed explanation for aerobic respiration. Recently, significant theoretical and experimental evidence were presented for an oxygen-centric 'murburn' mechanism of mitochondrial ATP-synthesis. Herein, we compare the predictive capabilities of the two models with respect to the available information on mitochondrial reaction chemistry and the membrane proteins' structure-function correlations.
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