A flexible loop in the paxillin LIM3 domain mediates its direct binding to integrin β subunits.

Integrins are fundamental for cell adhesion and the formation of focal adhesions (FA). Accordingly, these receptors guide embryonic development, tissue maintenance, and haemostasis but are also involved in cancer invasion and metastasis. A detailed understanding of the molecular interactions that drive integrin activation, FA assembly, and downstream signalling cascades is critical.

Tetra-chloridodi-μ3-oxido-tetra-kis-(μ2-propan-2-olato-κ(2) O:O)ditin(II)ditin(IV).

The centrosymmetric tetranuclear title molecule, [Sn4(C3H7O)4Cl4O2], contains two types of Sn atoms, Sn(II) and Sn(IV). The Sn(II) atom has a trigonal-pyramidal coordination environment and is bonded to two O atoms from two iso-propano-late groups and one μ3-oxide atom. The Sn(IV) atom has an octa-hedral coordination environment, formed by two chloride atoms, two μ3-oxide atoms and two O atoms from iso-propano-late groups.

Bis(μ-propan-2-olato-κO:O)bis-[chlor-ido(propan-2-ol-κO)bis-(pro-pan-1-ol-ato-κO)tin(IV)].

The binuclear centrosymmetric title compound, [Sn(2)(C(3)H(7)O)(6)Cl(2)(C(3)H(8)O)(2)], exhibits an edge-shared double octahedral exhibits an edge-shared octa-hedral structure, which is distorted owing to the presence of asymmetric intra-molecular hydrogen bonds between the axially coordinated isopropanol and isopropoxide ligands. The H atom of the hy-droxy group is located nearer to an isoprop-oxy group with the longest Sn-O bond [2.1789 (17) Å].

(N,N,N',N'-Tetra-methyl-ethylenediamine-κN)bis-(2,4,6-trimethyl-phenolato-κO)germanium(II).

In the title compound, [Ge(C(9)H(11)O)(2)(C(6)H(16)N(2))], the Ge(II) atom is coordinated in a distorted trigonal-pyramidal geometry by two O atoms belonging to two 2,4,6-trimethyl-phenolate ligands and one N atom of a tetra-methyl-ethylenediamine ligand. Comparing the structure with published data of similar compounds shows that the Ge-O bonds are covalent and the Ge-N bond is coordinated.