Publications by authors named "Nikolai Kapranov"
Immune system and bone marrow stromal cells play an important role in maintaining normal hematopoiesis. Lymphoid neoplasia disturbs not only development of immune cells, but other immune response mechanisms as well. Multipotent mesenchymal stromal cells (MSCs) of the bone marrow are involved in immune response regulation through both intercellular interactions and secretion of various cytokines.
View Article and Find Full Text PDFBackground: It is well known that the disease progression in cystic fibrosis (CF) patients may be diverse in subjects with identical mutation in CFTR gene. It is quite possible that such heterogeneity is associated with TNF-α and/or LT-α gene polymorphisms since their products play a key role in inflammation. The aim of the study was to investigate the possible roles of TNF gene polymorphisms in CF disease phenotype and progression.
View Article and Find Full Text PDFA formulation of aerosolized tobramycin (Bramitob) in the treatment of patients with cystic fibrosis and Pseudomonas aeruginosa infection: a double-blind, placebo-controlled, multicenter study.
Paediatr Drugs
September 2007
Article Synopsis
- Objective
- : The study aimed to evaluate the effectiveness and safety of a highly concentrated tobramycin inhalation solution (TSI) in treating chronic Pseudomonas aeruginosa infections in cystic fibrosis (CF) patients who are already on other antipseudomonal therapies.
- Methodology
- : In a double-blind, multicenter trial, 247 CF patients were randomly assigned to receive either nebulized tobramycin or a placebo over 24 weeks, with alternating treatment cycles, and various lung function and microbiological outcomes were measured.
- Results
- : At the 20-week mark, patients receiving TSI showed a significant improvement in lung function (FEV1) compared to
Background: Fecal elastase-1 (E1) test is a sensitive and specific indirect test. However, there are few data on the best cut-off level in the assessment of exocrine pancreatic function in cystic fibrosis (CF).
Material And Methods: In 725 CF patients and 243 healthy subjects (HS) from Greece, Russia, Poland and the United Kingdom, E1 concentrations were measured.
Background And Aim: Macrolide antibiotics are widely used in the treatment of suppurative lung diseases including cystic fibrosis (CF), the most common inherited fatal disease in the Caucasian population. This condition is characterized by secondary Pseudomonas infection resulting in neutrophil infiltration within the airways. The aim of the study was to investigate the evolution of inflammatory process in CF patients receiving long-term clarithromycin therapy.
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