Resveratrol induces apoptosis and alters gene expression in human fibrosarcoma cells.

Background/aim: Metastatic fibrosarcomas still represent a therapeutic dilemma. Commonly used chemotherapeutic agents such as doxorubicin have been proven effective in fewer than 30% of all cases disseminated of fibrosarcoma. Elderly patients with cardiac disease are not suitable for systemic chemotherapy with doxorubicin.

Changes of oxygenation and hemoglobin-concentration in lower extremity free flaps during dangling.

Lower extremity reconstruction utilizing free tissue transfer has become a common and safe procedure. Postoperative care and especially timing and duration of dangling however have not yet been extensively studied. We therefore aimed to assess the changes in oxygenation and hemoglobin concentration in lower extremity free flaps during dangling.