[Laser reflexotherapy in the combined treatment of neurogenic bladder dysfunction in children with caudal regression syndrome].

The authors propose to introduce low-energy laser reflexotherapy to the complex of rehabilitative therapy for children with neurogenic dysfunction of the urinary bladder. The laser causes no pain, which enables the procedure to be used in infants, eliminates unretarded contractions of a detrusor rather effectively. A continuous reproduction of this therapeutic complex can be achieved by a relatively long-term stabilization of urination in a third of the children.

[Reconstructive microsurgery in the combined treatment of children with spinal cord disorders].

The use of microsurgical techniques in operations for autoneuroplasty with intercostal nerves in patients with congenital abnormality of the spinal cord makes it possible to adequately approximate of the interrupted roots of the spinal cord and creates promising prerequisites for restoration of pelvic and motor functions. Observations have shown that the functions of the pelvic organs in children are gradually restored and active movements appear in the lower extremities. The use of the omentum on a nutrient pedicle made it possible to arrest hydrocephalic phenomena.

[The characteristics of the action of polyphytochol on the course of experimental hepatitis and cholecystitis].

The effect of polyphytochol representing a combination of vegetable agents was studied on models of acute toxic hepatitis caused by CCl4 and cholecystitis. The efficiency of the drug in pathology of the hepatobiliary system was shown: it decreases cholestasis acting as a choleretic and bile-secreting drug, acts on the main pathogenetic links in hepatitis, exerts a marked membrane-stabilizing effect, influences favourably the processes of synthesis in the liver.

[A comparison of the hormonal and etholotropic activity of luliberin and its analogs].

The paper is devoted to comparative analysis of the activity of peptides (LH-RH analogs) with relation to their action on ovulation as well as on the learning capabilities and their effect on immobilization stress in rats. The acceleration of learning processes and elimination of immobilization stress were shown to be caused by LH-RH and its analogs, regulating actively ovulation under experimental conditions. The comparative evaluation of their action has shown that LH-RH analogs-antagonists produce a more marked effect on the process of learning and elimination of stress consequences than its analogs-agonists.

[Effect of antihepatotoxic tea on the course of drug-induced hepatitis].

Pharmacotherapeutic efficacy of antihepatoxic tea was studied on an experimental model of tetracycline-induced hepatitis. It was concluded that the tea had a marked pharmacotherapeutic effect on the process of tetracycline-induced hepatitis in animals. It lowered the level of the cytolytic syndrome, prevented the progress of cholestasis and stimulated the bile secretory function of the liver.

[The range of potential practical use for luliberin as a neurotropic peptide].

Some aspects of the effect of LH-RH on behavior reactions and CNS activity were investigated. LH-RH was shown to produce a positive effect on teaching processes in animals, to possess analgesic and antispasmodic activity, and to activate the central nervous system. The adaptogenic properties of LH-RH necessitated a study of its potential to stop dysadaptation.

[Effect of kaleflon on the course of experimental hepatitis].

A pronounced cholagogic effect of kaleflon was found in the experiment on albino rats. The course administration of kaleflon in a dose of 0.05 g/kg exerts a marked pharmacotherapeutic action on the course of experimental hepatitis.

[Effect of a cyclic luliberin analog on ovulation].

A study was made of the cyclic LH-RH analog and its linear precursor on infantile and mature female rats. The compounds showed various biological properties which manifested themselves in their effects on ovulation. The linear analog proved to be an antagonist and the cyclic analog the LH-RH agonist.

[Experimental antioxidant pharmacotherapy of liver injuries].

It has been shown in rats with experimental hepatitis that sodium selenite and vegetable polyphenol complexes of Malus Pallasiana Juz., Schabiosa comosa F ex. R.

Summary of experiments onboard Soviet biosatellites.

Physiological, morphological and biochemical studies of mammals flown onboard biosatellites of the series Cosmos revealed changes in their cardiovascular, musculoskeletal, endocrine and vestibular systems. Space flight resulted in moderate stress reactions, intralabyrinthine conflict information during movements and changes in fluid-electrolyte metabolism. Exposure to artificial gravity (1 g) decreased the level of myocardial, musculoskeletal and excretory changes, but disturbed the function of equilibrium.

[Effect of sodium selenite, alpha-tocopherol and their combinations on the indices of the functional state of the heart regulation adren- and cholinergic systems in experimental myocardial infarct].

A course-wise administration of sodium selenate (30 gamma/kg), alpha-tocopherol (50 mg/kg) and of their combination in the same doses brings down the catecholamines content in the heart and suprarenals in the acute period of developing myocardial infarction (2nd day) with its subsequent normalization on the 14th day. Under the effect of these drugs the proportion of acetylcholine-like substances in the heart with experimental infarction rises at the expense of an accruing free (unbound with protein) fraction. The cholinesterase activity then gets intensified in the acute period and becomes normal by the 14th day.

[Therapeutic-preventive effect of sodium selenite on the course of experimental myocardial infarct].

An occlusion of the left coronary artery in rats tends to signally raise the intensity of free radical oxidation of myocardial-lipids, which is revealed by the chemofluorescent method. A direct correlational link between the intensity of the lipids peroxidation and the extent of the myocardial damage was established. Subcutaneous injection of sodium selenite in a dose of 30 gamma/kg 2 hours prior to ligation and once daily for a space of 7 days produces a distincly reduced intensity of free-radical processes in the myocardium, decreases the extent of infarction and prevents the appearance of gross changes on the ECG.