Publications by authors named "Nikola Sobczak"
J Leukoc Biol
September 2024
Article Synopsis
- A significant number of genetically modified mice have been created from 129 strain-derived embryonic stem cells (ESCs), which may carry extra mutations affecting their phenotypes.
- The study reveals that the Ackr1-/-129ES mice retain a large segment of the 129 genome next to the Ackr1 gene, which can influence the expression of genes related to immune response.
- Researchers advise caution in interpreting the effects of ACKR1 deficiency in these mice, highlighting the need to reassess findings from past studies that utilized this mouse model due to potential confounding results.
