Publications by authors named "Nikola Mielniczek"
Bisphenols belong to the group of environmental pollutants with proven harmful impact on human red blood cells. However, the exact effect of these substances may vary depending on the lipid composition of the cell membrane, since this structure is the first barrier between the cell interior and the external environment. The aim of this work was to analyze the influence of bisphenol A (BPA), bisphenol S (BPS) and their 1:1 mixture on model human erythrocyte membranes, composed of sphingomyelin (SM), phospatidylcholine (PC) and cholesterol (Chol).
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- - This paper investigates how tunicamycin (Tu), a common drug used to induce endoplasmic reticulum (ER) stress, affects endothelial cells by entering them and accumulating in the ER.
- - The study utilizes Raman spectroscopy and scanning electron microscopy to explore changes in the biochemical makeup of these cells under ER stress but notes that specific markers for these changes have yet to be identified.
- - The research highlights a significant reduction in phospholipid content within the ER area, pinpointing sphingomyelin as the most abundant phosphorus-containing lipid affected by Tu treatment.