Modelling of endothelial cell migration and angiogenesis in microfluidic cell culture systems.

Tumour-induced angiogenesis is a complex biological process that involves growth of new blood vessels within the tumour microenvironment and is an important target for cancer therapies. Significant efforts have been undertaken to develop theoretical models as well as in vitro experimental models to study angiogenesis in a highly controllable and accessible manner. Various mathematical models have been developed to study angiogenesis, but these have mostly been applied to in vivo assays.