Publications by authors named "Nikola Chmurciakova"
Article Synopsis
- Non-canonical structures (NCS) are different forms of DNA that deviate from the classic B-conformation, and they play important roles in the genome's functions.
- The review highlights nine specific types of NCS found or expected in human ribosomal DNA, such as G-quadruplexes and i-motifs, along with their significance.
- Key topics include how these structures form, where they are located in the DNA, their behavior, and their potential positive or negative effects on cells.
Human ribosomal DNA is represented by hundreds of repeats in each cell. Every repeat consists of two parts: a 13 kb long 47S DNA with genes encoding 18S, 5.8S, and 28S RNAs of ribosomal particles, and a 30 kb long intergenic spacer (IGS).
View Article and Find Full Text PDFIn human cells, each rDNA unit consists of the ~13 kb long ribosomal part and ~30 kb long intergenic spacer (IGS). The ribosomal part, transcribed by RNA polymerase I (pol I), includes genes coding for 18S, 5.8S, and 28S RNAs of the ribosomal particles, as well as their four transcribed spacers.
View Article and Find Full Text PDFIn human cells, ribosomal DNA (rDNA) is arranged in ten clusters of multiple tandem repeats. Each repeat is usually described as consisting of two parts: the 13 kb long ribosomal part, containing three genes coding for 18S, 5.8S and 28S RNAs of the ribosomal particles, and the 30 kb long intergenic spacer (IGS).
View Article and Find Full Text PDFEctoparasitic monogeneans of the family Diplozoidae have direct and monoxenous life cycle. The cytogenetics of monogeneans in general and diplozoids in particular, is a relatively underexplored area. This is why each new detailed description of a karyotype provides significant information about the evolution of monogenean chromosomes and contributes to a better understanding of phylogenetic relationships within this group.
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