Multiscale Modeling Indicates That Temperature Dependent [Ca2+]i Spiking in Astrocytes Is Quantitatively Consistent with Modulated SERCA Activity.

Changes in the cytosolic Ca(2+) concentration ([Ca(2+)]i) are the most predominant active signaling mechanism in astrocytes that can modulate neuronal activity and is assumed to influence neuronal plasticity. Although Ca(2+) signaling in astrocytes has been intensively studied in the past, our understanding of the signaling mechanism and its impact on tissue level is still incomplete. Here we revisit our previously published data on the strong temperature dependence of Ca(2+) signals in both cultured primary astrocytes and astrocytes in acute brain slices of mice.

Order parameter expansion and finite-size scaling study of coherent dynamics induced by quenched noise in the active rotator model.

We use a recently developed order parameter expansion method to study the transition to synchronous firing occurring in a system of coupled active rotators under the exclusive presence of quenched noise. The method predicts correctly the existence of a transition from a rest state to a regime of synchronous firing and another transition out of it as the intensity of the quenched noise increases and leads to analytical expressions for the critical noise intensities in the large coupling regime. It also predicts the order of the transitions for different probability distribution functions of the quenched variables.

Drug absorption through a cell monolayer: a theoretical work on a non-linear three-compartment model.

The subject of analysis is a non-linear three-compartment model, widely used in pharmacological absorption studies. It has been transformed into a general form, thus leading automatically to an appropriate approximation. This made the absorption profile accessible and expressions for absorption times, apparent permeabilities and equilibrium values were given.