Publications by authors named "Nikkita Dutta"
Article Synopsis
- A study analyzed the costs and impacts of starting or delaying ofatumumab treatment for relapsing-remitting multiple sclerosis (MS) patients in Canada using a Markov cohort model over ten years.* -
- Ofatumumab showed better health outcomes, like fewer relapses and improved job productivity, while also lowering treatment-related costs compared to other high-efficacy MS therapies.* -
- The findings suggest that beginning treatment with ofatumumab sooner rather than later can lead to enhanced health benefits for newly diagnosed patients with active MS.*
Mutations in the transmembrane protein nephrin (encoded by NPHS1) underlie nearly half of all cases of congenital nephrotic syndrome (CNS), which is caused by aberrations in the blood filtering function of glomerular podocytes. Nephrin directly contributes to the structure of the filtration barrier, and it also serves as a signaling scaffold in podocytes, undergoing tyrosine phosphorylation on its cytoplasmic tail to recruit intracellular effector proteins. Nephrin phosphorylation is lost in several human and experimental models of glomerular disease, and genetic studies have confirmed its importance in maintenance of the filtration barrier.
View Article and Find Full Text PDF