Hyperosmolar irrigation compared with a standard solution in a canine shoulder arthroscopy model.

Background: A hyperosmolar irrigation solution may decrease fluid extravasation during arthroscopic procedures. Demonstrating the safety of a hyperosmolar irrigation solution with respect to chondrocyte viability and cartilage water content was deemed necessary before designing a clinical efficacy study.

Methods: We designed a translational animal model study in which hyperosmolar arthroscopy irrigation fluid (1.