Publications by authors named "Nikki Prpic"
J Immunol Methods
July 2011
Article Synopsis
- The study investigates the use of antibodies targeting minichromosome maintenance proteins MCM6 and MCM7 to improve the detection of cervical disease, as current screening methods like the Papanicolaou test miss some cases.
- Researchers screened hybridoma clones against tissue samples to identify specific antibodies, ultimately selecting two (2E6.7 for MCM7 and 9D4.3 for MCM6) based on their strong performance in recognizing abnormal cervical cells with minimal interference from normal tissues.
- Findings include the successful characterization of the antibodies' epitopes and their high affinity, suggesting potential for enhanced sensitivity in cervical cancer detection through immunocytochemistry.
