LOGAN-CV: A Prospective Study of a Multifaceted Intervention Targeting United States Clinicians to Improve Guideline-Based Management of Lipid-Lowering Therapy.

Introduction: The 2018 American Heart Association (AHA)/American College of Cardiology (ACC)/Multisociety blood cholesterol guidelines recommend clinicians consider adding non-statin therapy for patients with very high-risk (VHR) atherosclerotic cardiovascular disease (ASCVD) and low-density lipoprotein cholesterol (LDL-C) ≥ 70 mg/dl while receiving maximally tolerated statins. However, according to a recent study, only 17.1% of patients with established ASCVD received appropriate lipid-lowering therapy (LLT) intensification.

Progestogens for preterm birth prevention: a systematic review and meta-analysis by drug route.

Purpose: Progestogen has been investigated as a preventive intervention among women with increased preterm birth risk. Our objective was to systematically review the effectiveness of intramuscular (IM), vaginal, and oral progestogens for preterm birth and neonatal death prevention.

Methods: We included articles published from January 1966 to January 2013 and found 27 randomized trials with data for Bayesian meta-analysis.

Progestogens for preterm birth prevention: a systematic review and meta-analysis.

Objective: We systematically reviewed the effectiveness of progestogens for prevention of preterm birth among women with prior spontaneous preterm birth, multiple gestations, preterm labor, short cervix, or other indications.

Data Sources: We searched MEDLINE and EMBASE databases for English language articles published from January 1966 to October 2011.

Methods Of Study Selection: We excluded publications that were not randomized controlled trials or had fewer than 20 participants, identifying 34 publications, of which 19 contained data for Bayesian meta-analysis.

Evidence to inform decisions about maternal-fetal surgery: technical brief.

Objective: To summarize the state of research in maternal-fetal surgery regarding the surgical repair of abnormalities in fetuses in the womb.

Data Sources: We searched MEDLINE from 1980 to 2010 for studies of maternal-fetal surgery for the following conditions: twin-twin transfusion syndrome, obstructive uropathy, congenital diaphragmatic hernia, myelomeningocele, thoracic lesions, cardiac malformations, and sacrococcygeal teratoma.

Methods Of Study Selection: We used pilot-tested data collection forms to screen publications for inclusion and to extract data.

Treatment of overactive bladder in women.

Objectives: The Vanderbilt Evidence-based Practice Center systematically reviewed evidence on treatment of overactive bladder (OAB), urge urinary incontinence, and related symptoms. We focused on prevalence and incidence, treatment outcomes, comparisons of treatments, modifiers of outcomes, and costs.

Data: We searched PubMed, MEDLINE, EMBASE, and CINAHL.

Reflections on the use of electronic health record data for clinical research.

The adoption of electronic health records (EHRs) offers the potential to improve the delivery, quality, and continuity of clinical care, but widespread use has not yet occurred. In this article, we describe our use of clinical (production) data that were derived from outpatient and inpatient visits at a university teaching hospital for clinical research, a use for which the data and their structure were not originally designed. Similar data exist at many outpatient and inpatient clinical facilities, and we believe that our insights are relevant to electronically captured medical data regardless of their origin.

Management of uterine fibroids: an update of the evidence.

Objectives: The RTI International-University of North Carolina at Chapel Hill Evidence-based Practice Center (RTI-UNC EPC) systematically updated evidence on the management of uterine fibroids, specifically incidence and prevalence of fibroids, treatment outcomes, comparisons of treatment, modifiers of outcomes, and costs.

Data Sources: We searched MEDLINE(R), Cochrane Collaboration resources, and Embase.

Review Methods: We included studies published in English from February 2000 through August 2006.