Publications by authors named "Nikka Khorsandi"

Background: Membranous nephropathy (MN) can develop post-kidney transplant and is classified as a recurrent disease in patients with a history of MN in the native kidneys or as disease in patients without such history. The mechanism of recurrent MN is thought to be like that of primary MN, but the mechanism of MN is not well delineated. An association between MN and antibody-mediated rejection (AMR) has been suggested.

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Fine needle aspiration biopsy (FNAB) in low- and middle-income countries (LMIC), can provide minimally invasive, cost-effective tissue diagnosis with rapid assessment and specimen triage, which is advantageous in these resource-limited settings. Nevertheless, challenges such as equipment shortages, reagents, and lack of trained personnel exist. This article discusses the effectiveness of FNAB for diagnosis of malignant and inflammatory conditions across various organs, such as lymph nodes, breast, soft tissue, and thyroid and advocates for increased training opportunities and collaboration with academic centers to enhance diagnostic accuracy and access to pathology services.

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The diagnosis of anal cancer is relatively uncommon, but its incidence has been steadily increasing in high-risk populations. In the 2001 Bethesda System for Reporting Cervical Cytology, anal cytology was introduced as a component. Since then, it has been recognized as a potential tool for screening anal cancer, often in conjunction with high-resolution anoscopy.

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Article Synopsis
  • CHEK2 germline variants are linked to a moderate increase in breast cancer risk, primarily affecting younger women, with a median age of 45.
  • The study analyzed 44 CHEK2-associated breast cancer cases, finding that most tumors were invasive ductal carcinomas (86%) and predominantly estrogen receptor positive (95%).
  • Despite variable responses to chemotherapy, 85% of patients remained disease-free during the follow-up, although some experienced metastasis, and one patient died over an average follow-up period of 50 months.
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Background: Cancer survivors face many financial burdens that generate additional stress such as housing insecurity or homelessness. Because this leads to worse health outcomes, it is essential for health care and housing organizations to begin mobilizing resources to support this vulnerable population.

Objectives: Create a "Housing in Cancer" workgroup to conduct systems-led analysis of housing insecurity in cancer survivorship in the Greater New Orleans area.

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Background: The use of cell block (CB) preparation is underused in urine cytology (UC) and varies among hospitals. In addition to confirming a diagnosis, CBs can be useful in cases of metastatic disease, diagnoses requiring immunohistochemical (IHC) staining, and for ancillary studies. The role of this study is to examine the performance of CBs for UC at three affiliated teaching hospitals.

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Introduction: There is a practice gap and educational need regarding urine cytology (UC) performance in patients with history of gender confirmation surgery (GCS) and/or hormone therapy (HT). This potentially impacts diagnostic accuracy in this medically underserved population. We report a methodology that identifies relevant cases and evaluates the performance of UC in this cohort.

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Objective: The American Academy of Pediatrics recommends that pediatricians provide a medical home for adolescent parents, and this study sought to determine pediatricians' compliance with this recommendation within the context of other adolescent reproductive health services provided.

Methods: An Internet-based survey was administered to Louisiana pediatricians. The survey contained 17 Likert scale questions relating to sexual and reproductive health services provided to female and male adolescents, and ascertaining their comfort and experience with issues related to the care of adolescents, including adolescent mothers.

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Successful university wellness programs approach wellness holistically and regularly assess for improvements to program offerings. This case-study reports five lessons learned from a university wellness program evaluation that must be considered when developing wellness programming. Faculty, staff, and students at a public university health sciences center.

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Study Objective: Adolescents face many barriers to obtaining emergency contraception (EC), despite it being an approved and recommended method to prevent unintended pregnancy. This study examined pharmacy-related barriers to adolescents' access to EC in Louisiana.

Design: Prospective, telephone-call secret shopper study to pharmacies to assess same-day EC availability and barriers to purchase.

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We assessed the same-day availability of oral emergency contraception (EC) in five Louisiana communities, and evaluated this data for relationships between availability and local population demographics. Researchers called all retail pharmacies in five municipalities of varying sizes in order to inquire about the same-day stockage of EC products and their availability to teens. Individual pharmacies were then geolocated to a census tract, and call data was analyzed against neighborhood census data regarding population size, income, gender, race, family structure, and educational level.

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GABAergic signaling from amacrine cells (ACs) is a fundamental aspect of visual signal processing in the inner retina. We have previously shown that nitric oxide (NO) can elicit release of GABA independently from activation of voltage-gated Ca channels in cultured retinal ACs. This voltage-independent quantal GABA release relies on a Ca influx mechanism with pharmacological characteristics consistent with the involvement of the transient receptor potential canonical (TRPC) channels TRPC4 and/or TRPC5.

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