Publications by authors named "Nikita Gladyshev"

Article Synopsis
  • Clarithromycin (CLR) is a crucial antibiotic for treating Helicobacter pylori infections, but there is a lack of data on resistance patterns in Russia.
  • Researchers used whole genome sequencing (WGS) to analyze 44 clinical H. pylori isolates from 2014-2022, finding that 23 were CLR-resistant while 21 were susceptible.
  • The study identified specific genetic mutations in the 23S rRNA gene that reliably predict resistance, and it also compared mutations in virulence-related genes between resistant and susceptible strains, highlighting a significant deletion in the HP0820 gene as a key area for future research.
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Despite great advances in the treatment of oncological diseases, the development of medical technologies to prevent or reduce complications of therapy, in particular, those associated with surgery and the introduction of antibiotics, remains relevant. The aim of this study is to evaluate the effectiveness of the use of autoprobiotics based on indigenous non-pathogenic strains of and as a personalized functional food product (PFFP) in the complex therapy of colorectal cancer (CRC) in the early postoperative period. A total of 36 patients diagnosed with CRC were enrolled in the study.

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Background: Helicobacter pylori eradication therapy can be considered effective if the result of its implementation is removed including all roots and rootlets from which surviving H. pylori can repopulate in the gastric mucosa. One of the reasons for the ineffectiveness of eradication therapy can be the continuous presence of viable coccoid forms of H.

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Metformin is a first-line drug for DM2 treatment and prevention, but its complex effect on impaired glucose tolerance (IGT), including its influence on myocardial resistance to ischemia-reperfusion injury, is not completely studied. We aimed to evaluate the influence of metformin on the intestinal microbiota (IM), metabolism, and functional and morphological characteristics of myocardium in rats with IGT. IGT was modelled in SPF Wistar rats with a high-fat diet and streptozotocin and nicotinamide injection.

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grows and multiplies in the gastrointestinal tract (GIT) in about half of the world's population. The prevalence of diseases associated with this bacterium is steadily increasing, which makes it necessary to search for optimal therapy aimed at eradication of this bacterium. Such diseases, for example, include gastric ulcer (GU) and chronic gastritis (CG).

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