Publications by authors named "Nikita G Shiliaev"
Article Synopsis
- The paper investigates the formation of Aβ amyloid fibrils using theoretical models and experimental techniques like electron microscopy and X-ray diffraction.
- It determines the sizes of the "nuclei" required to form these fibrils, finding that Aβ42 has a primary nucleus of 3 monomers and a secondary nucleus of 2, while Aβ40 has a primary nucleus of 2 monomers and a secondary nucleus of 1.
- The study proposes a new model for amyloid fibril organization, suggesting that therapy targets should focus on specific oligomer sizes (tetramers for Aβ42 and trimers for Aβ40) to effectively inhibit their formation.
Search for conserved amino acid residues of the α-crystallin proteins of vertebrates.
J Bioinform Comput Biol
April 2016
[Formula: see text]-crystallin is the major eye lens protein and a member of the small heat-shock protein (sHsp) family. [Formula: see text]-crystallins have been shown to support lens clarity by preventing the aggregation of lens proteins. We performed the bioinformatics analysis of [Formula: see text]-crystallin sequences from vertebrates to find conserved amino acid residues as the three-dimensional (3D) structure of [Formula: see text]-crystallin is not identified yet.
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