Publications by authors named "Nikita A Nekliudov"

Article Synopsis
  • The study analyzed data from over 689,000 hospitalized COVID-19 patients across 52 countries from January 2020 to January 2022, examining demographic characteristics, symptoms, co-morbidities, and treatment outcomes.
  • Key findings indicate that older age and male sex significantly increased the risk of death, with the hazard ratio for age being 1.49 per 10 years, while the case-fatality ratio averaged 21.5% and varied by country.
  • The research highlights that age is the primary risk factor for mortality, with significant associations found for co-morbidities, smoking, and obesity, providing valuable insights for clinical strategies to address COVID-19.
View Article and Find Full Text PDF

Importance: Some individuals experience persistent symptoms after initial symptomatic SARS-CoV-2 infection (often referred to as Long COVID).

Objective: To estimate the proportion of males and females with COVID-19, younger or older than 20 years of age, who had Long COVID symptoms in 2020 and 2021 and their Long COVID symptom duration.

Design, Setting, And Participants: Bayesian meta-regression and pooling of 54 studies and 2 medical record databases with data for 1.

View Article and Find Full Text PDF

Importance: While much of the attention on the COVID-19 pandemic was directed at the daily counts of cases and those with serious disease overwhelming health services, increasingly, reports have appeared of people who experience debilitating symptoms after the initial infection. This is popularly known as long COVID.

Objective: To estimate by country and territory of the number of patients affected by long COVID in 2020 and 2021, the severity of their symptoms and expected pattern of recovery.

View Article and Find Full Text PDF

Background: The psychological effects from the COVID-19 pandemic and response are poorly understood.

Objective: To understand the effects of the pandemic and response on anxiety and health utility in a nationally representative sample of US adults.

Design: A de-identified, cross-sectional survey was administered at the end of April 2020.

View Article and Find Full Text PDF

IgE-mediated food allergies are caused by adverse immunologic responses to food proteins. Allergic reactions may present locally in different tissues such as skin, gastrointestinal and respiratory tract and may result is systemic life-threatening reactions. During the last decades, the prevalence of food allergies has significantly increased throughout the world, and considerable efforts have been made to develop curative therapies.

View Article and Find Full Text PDF

Background: The epidemiology, clinical course, and outcomes of patients with coronavirus disease 2019 (COVID-19) in the Russian population are unknown. Information on the differences between laboratory-confirmed and clinically diagnosed COVID-19 in real-life settings is lacking.

Methods: We extracted data from the medical records of adult patients who were consecutively admitted for suspected COVID-19 infection in Moscow between 8 April and 28 May 2020.

View Article and Find Full Text PDF

Human breast milk (HM) contains multiple bioactive substances determining its impact on children's health. Extracellular vesicles (EVs) are a heterogeneous group of secreted nanoparticles that are present in HM and may be partially responsible for its beneficial effects. The precise roles and content of EVs in HM remain largely unknown.

View Article and Find Full Text PDF

Background: The COVID-19 pandemic has potentially had a negative impact on the mental health and well-being of individuals and families. Anxiety levels and risk factors within particular populations are poorly described.

Objective: This study aims to evaluate confidence, understanding, trust, concerns, and levels of anxiety during the COVID-19 pandemic in the general population and assess risk factors for increased anxiety.

View Article and Find Full Text PDF

Background: Colorectal anastomotic leakage (AL) is one of the most serious complications in rectal cancer surgery due to its negative impact on the overall as well as cancer-specific survival. Two-row stapling technique has become standard in low anterior resections (LARs), but has neither alleviated the morbidity, nor reduced the incidence of AL. This is the 1st study that aims to compare the success rate of new 3-row circular staplers compared to that of conventional 2-row staplers in a prospective, randomized clinical trial.

View Article and Find Full Text PDF