Publications by authors named "Nikil Wagle"
Article Synopsis
- Tissue biology relies on understanding both individual cell functions and the way cells interact in specific arrangements, which can be studied using techniques like single-cell RNA sequencing (scRNA-seq) and histological imaging (H&E stains).
- While single-cell profiles give detailed molecular insights, they lack spatial context and can be hard to gather regularly, whereas H&E stains provide structural information but not direct molecular data.
- The newly developed framework SCHAF utilizes adversarial machine learning to create spatially-resolved single-cell omics data from H&E images, demonstrating its effectiveness on human tumor samples and paving the way for enhanced tissue analysis in biomedical research.
