Publications by authors named "Niki Sharan"
Article Synopsis
- The Neu gene (HER2) is linked to breast cancer and was studied in a mouse model to assess the role of increased angiogenic signaling.
- Transgenic mice expressing higher levels of vascular endothelial growth factor (VEGF) showed normal mammary development but, when combined with the NeuYD oncogene, exhibited accelerated tumor growth, decreasing the time to tumor appearance significantly.
- The study found that the enhanced vascularization in tumors was associated with changes in cell organization and indicated a unique mechanism of metastasis that does not rely on traditional invasion pathways.
Activation of the epidermal growth factor receptor (EGFR) family is thought to play an important role in mammary tumorigenesis and metastasis. The potent transforming activity of the EGFR family is due to their ability to heterodimerize with each other in response to a number of mitogenic ligands. The formation of EGFR and ErbB-2 heterodimers has been recently implicated as an important factor in the induction of sporadic human breast cancers.
View Article and Find Full Text PDFPrevious reports from our laboratory have described brain-specific catecholamine-regulated proteins, which bind dopamine and related catecholamines. Evidence from the molecular cloning of a 40 kDa catecholamine-regulated protein (CRP40) revealed that CRP40 is dopamine-inducible and has properties similar to those of the 70 kDa heat shock protein (HSP70) family. The present study investigates the effects of acute and chronic cocaine treatment on CRP40 expression in the striatum, nucleus accumbens, prefrontal cortex, and medulla.
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