Publications by authors named "Niki Kappa"
Article Synopsis
- Members of the α-thymosin family, particularly prothymosin α (proTα) and its peptide proTα(100-109), have been shown to boost T helper type 1 (Th1) immune responses and enhance antitumor T cell activity both in the lab and in living organisms.
- Safety assessments in silico, in human cells, and in healthy mice indicated that proTα and proTα(100-109) are likely non-toxic and do not promote harmful effects, similar to the established safety of thymosin alpha 1 (Tα1).
- Overall, the research suggests that proTα and proTα(100-109) are safe at high concentrations and maintain
Aim: Rasagiline mesylate (N-propargyl-1 (R)-aminoindan) (RG) is a selective, potent irreversible inhibitor of monoamine oxidase-B with cardioprotective and anti-apoptotic properties. We investigated whether it could be cardioprotective in a rat model undergoing experimental myocardial infarction (MI) by permanent ligation of the left anterior descending coronary artery.
Methods And Results: RG was administered, intraperitoneally, for 28 days (2 mg/kg) starting 24 h after MI induction.