Reconsidering red blood cells as the diagnostic potential for neurodegenerative disorders.

Background: Red blood cells (RBCs) are usually considered simple cells and transporters of gases to tissues.

Hypothesis: However, recent research has suggested that RBCs may have diagnostic potential in major neurodegenerative disorders (NDDs).

Results: This review summarizes the current knowledge on changes in RBC in Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and other NDDs.