Publications by authors named "Nikhil Vojjala"
Article Synopsis
- Anticholinergic toxicity and neuroleptic malignant syndrome (NMS) are both serious conditions that can occur together, but this combination is rare and complicated to treat.* * A 23-year-old male with a history of substance dependence was admitted due to toxicity from both trihexyphenidyl and risperidone, leading to a diagnosis of dual toxidrome.* * Treatment involved medications like lorazepam and bromocriptine for NMS, while intrathecal neostigmine was used as an alternative when the preferred antidote, physostigmine, wasn't available; the patient eventually recovered.*
Stone heart syndrome has a complex interaction with digoxin toxicity, where, theoretically, the administration of intravenous calcium can worsen a patient's condition. Research on this subject is conflicting, so it is imperative to approach it cautiously.
View Article and Find Full Text PDFBleeding diathesis is an uncommon side effect of ibrutinib use and is seen in less than 5% of the population. We describe a case of an elderly woman with ibrutinib-induced spontaneous major extradural haematoma presenting as acute compressive myelopathy. She is a known case of splenic marginal zone lymphoma with multiple extramedullary relapses and presented to the emergency department with acute-onset low backache, followed by urinary retention.
View Article and Find Full Text PDFBlood transfusion is a common therapeutic intervention in hospitalized patients. There are numerous indications for transfusion, including anemia and coagulopathy with deficiency of single or multiple coagulation components such as platelets or coagulation factors. Nevertheless, the practice of transfusion in critically ill patients has been controversial mainly due to a lack of evidence and the need to consider the appropriate clinical context for transfusion.
View Article and Find Full Text PDFChemotherapy-induced cardiac dysfunction (CIC) is a significant and concerning complication observed among cancer patients. Despite the demonstrated cardioprotective benefits of statins in various cardiovascular diseases, their effectiveness in mitigating CIC remains uncertain. This meta-analysis aims to comprehensively evaluate the potential cardioprotective role of statins in patients with CIC.
View Article and Find Full Text PDFArticle Synopsis
- - The text discusses the occurrence of cardiovascular complications following medical termination of pregnancy (MTP) in the U.S., highlighting that around 1 million MTPs occur annually, with 2% developing complications.
- - The review identifies the most common complications such as infective endocarditis (IE), takotsubo cardiomyopathy (TTC), arrhythmias, and sudden coronary artery dissection, noting specific details about each condition and associated risks.
- - The conclusion emphasizes that cardiovascular complications post-MTP are underreported, with IE and TTC being the most common issues, but generally, clinical recovery is achievable with appropriate medical care.
Article Synopsis
- Telemedicine is being evaluated for its effectiveness in providing consultations for hepatobiliary disorders, showing promising results with 82% of consultations deemed suitable.
- The study identified factors influencing consultation suitability, where skilled occupation, higher education, and certain liver diseases like chronic hepatitis B, C, and NAFLD were linked to higher suitability, while conditions like cirrhosis and biliary obstruction were less suitable.
- Machine learning models, particularly the decision tree, effectively predicted consultation suitability, helping to categorize which patients could be effectively managed via telemedicine.
Article Synopsis
- Myoedema is an often overlooked neurological sign that can aid in diagnosing metabolic or endocrine-related muscle diseases.
- When myoedema is identified alongside pseudo-hypertrophy, it strongly suggests hypothyroid myopathy.
- Recognizing myoedema can help avoid unnecessary tests and streamline the diagnosis process.