Publications by authors named "Nikhil Titkare"
Article Synopsis
- Linaclotide (LINA) is a medication for treating constipation-related conditions, and researchers studied its stability under various stress conditions to meet international guidelines.
- A new liquid chromatography method was developed to separate and identify LINA's degradation products, using advanced techniques like high-resolution mass spectrometry.
- The study found that LINA degrades under different conditions, leading to the formation of seven degradation products, which were characterized and could help improve drug formulations in the future.
Mass spectrometry (MS) plays a crucial role in metabolomics, especially in the discovery of disease biomarkers. This review outlines strategies for identifying metabolites, emphasizing precise and detailed use of MS techniques. It explores various methods for quantification, discusses challenges encountered, and examines recent breakthroughs in biomarker discovery.
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